Vigilancia Tecnológica

The present application relates to the technical field of biomedical materials, and in particular, to a composite gel containing calcium hydroxyapatite microspheres having a core-shell structure, a preparation method therefor, and a use thereof. The composite gel comprises a gel carrier and microspheres dispersed in the gel carrier, the microspheres each comprise a core and a shell layer covering the core, the core is a biodegradable polymer, and the shell layer is calcium hydroxyapatite. After the composite gel containing calcium hydroxyapatite microspheres having a core-shell structure of the present application is implanted, calcium hydroxyapatite first comes into contact with human tissue and is degraded into calcium ions and phosphate ions, to stimulate collagen production for tissue remodeling; subsequently, the biodegradable polymer is also metabolically degraded; in addition, the degradation rate of calcium hydroxyapatite can control the exposure rate of the polymer microspheres, to achieve a long-term full filling effect. The gel has suitable viscoelasticity, so that the composite microspheres are uniformly suspended, and after being injected into a human body, the microspheres are still evenly dispersed in the gel.