The present disclosure relates, at least in part, to self-assembling peptides comprising a plurality of self-assembly repeat units that promote the formation of larger scale structures, such as a hydrogel. In some embodiments, a polymer described herein comprises a self-assembling and a cargo molecule, such as a peptide, polypeptide, or protein. In some embodiments, a cargo is a therapeutic cargo. Polymer assemblies described herein, such as those comprised in hydrogels, are useful for delivering therapeutic cargos to cells and may be used to treat a disease, disorder, or condition in a subject. The present disclosure further relates to methods of producing polymer assemblies and administration of polymer assemblies to a subject in need thereof.
Fecha publicación: 2025/05/22
Número: WO2025106582A1 (A1)
Solicitante: UNIV FLORIDA?[US]
Inventor: HILL ERIC D?[US]; HUDALLA GREGORY ALLAN?[US] (1)