Vigilancia Tecnológica

This study presents the development and characterization of injectable nanocomposite hydrogels based on N?succinyl chitosan, oxidized guar gum, and bacterial cellulose nanofibers. Emphasizing enhanced mechanical properties and biocompatibility, the hydrogels exhibit fast gelation, improved structural integrity, and reduced swelling. Their potential for minimally invasive applications and tissue engineering is supported by comprehensive chemical, mechanical, and biological evaluations.Demand is increasing for devices capable of regenerating or replacing damaged tissues, highlighting the need for advanced biomaterials. Hydrogels are promising for regenerative medicine, but often lack mechanical strength. To overcome this, a novel nanocomposite hydrogel based on N?succinyl chitosan (NSC) and oxidized guar gum (OxGG) reinforced with bacterial cellulose nanofibers (BCFs) is developed. These hydrogels are produced through a simple and safe Schiff?base reaction and hydrogen bonding, avoiding potentially toxic cross?linker or external stimuli. Chemical characterization is performed using Fourier transform infrared, X?ray photoelectron spectroscopy, and thermogravimetric analysis. Scanning electron microscopy reveals significant changes in the hydrogel's internal structure after BCF incorporation, resulting in a more compact and organized porous matrix. This modification also reduces phosphate buffer solution uptake, modifying the swelling behavior of the hydrogel, due to the formation of a rigid polymeric network. Both hydrogels exhibit fast gelation times (